Volume 89, Number 5, March 2010
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||22 March 2010|
Turnover of messenger RNA: Polysome statistics beyond the steady state
Max Planck Institute of Colloids and Interfaces, Department of Theory and Bio-Systems Potsdam, Germany, EU
2 University of Potsdam, Institute of Biochemistry and Biology - Potsdam, Germany, EU
Corresponding author: email@example.com
Accepted: 17 February 2009
The interplay between turnover or degradation and ribosome loading of messenger RNA (mRNA) is studied theoretically using a stochastic model that is motivated by recent experimental results. Random mRNA degradation affects the statistics of polysomes, i.e., the statistics of the number of ribosomes per mRNA as extracted from cells. Since ribosome loading of newly created mRNA chains requires some time to reach steady state, a fraction of the extracted mRNA/ribosome complexes does not represent steady state conditions. As a consequence, the mean ribosome density obtained from the extracted complexes is found to be inversely proportional to the mRNA length. On the other hand, the ribosome density profile shows an exponential decrease along the mRNA for prokaryotes and becomes uniform in eukaryotic cells.
PACS: 87.10.Mn – Stochastic modeling / 87.14.gn – RNA / 87.15.A- – Theory, modeling, and computer simulation
© EPLA, 2010
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.