Volume 92, Number 2, October 2010
|Number of page(s)||6|
|Section||Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics|
|Published online||15 November 2010|
Obstacle design for pressure-driven vector chromatography in microfluidic devices
National University of Singapore, Department of Physics - 2 Science Drive 3, Singapore 117542
2 Department of Physics, The Chinese University of Hong Kong - Shatin, Hong Kong, China
Accepted: 4 October 2010
A mechanism that breaks the symmetry of fluid flows in microfluidic arrays of obstacles and hence facilitates pressure-driven vector chromatography is introduced. The proposed mechanism allows a fraction of the flow to penetrate the obstacles, while the immersed particles are sterically excluded. Based on Lattice-Boltzmann simulations of the fluid flow, it is investigated how and to what extent the symmetry of the flow is broken. The key characteristics of the separation process are estimated by means of Brownian ratchet theory and validated with Brownian dynamics simulations.
PACS: 47.61.-k – Micro- and nano- scale flow phenomena / 05.40.Jc – Brownian motion
© EPLA, 2010
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.