Volume 93, Number 5, March 2011
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||10 March 2011|
Stochastic kinetics of a single-headed motor protein: Dwell time distribution of KIF1A
Department of Physics, Indian Institute of Technology - Kanpur 208016, India
Accepted: 11 February 2011
KIF1A, a processive single-headed kinesin superfamily motor, hydrolyzes adenosine triphosphate (ATP) to move along a filamentous track called microtubule. The stochastic movement of KIF1A on the track is characterized by an alternating sequence of pause and translocation. The sum of the durations of pause and the following translocation defines the dwell time. Using the NOSC model (Nishinari K. et al., Phys. Rev. Lett., 95 (2005) 118101) of individual KIF1A, we systematically derive an analytical expression for the dwell time distribution. More detailed information is contained in the probability densities of the “conditional dwell times” τ±± in between two consecutive steps each of which could be forward (+) or backward (−). We calculate the probability densities Ξ±± of these four conditional dwell times. However, for the convenience of comparison with experimental data, we also present the two distributions Ξ±* of the times of dwell before a forward (+) and a backward (−) step. In principle, our theoretical prediction can be tested by carrying out single-molecule experiments with adequate spatio-temporal resolution.
PACS: 87.16.ad – Analytical theories / 87.16.Nn – Motor proteins (myosin, kinesin dynein) / 87.10.Mn – Stochastic modeling
© EPLA, 2011
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.