| Issue |
EPL
Volume 96, Number 6, December 2011
|
|
|---|---|---|
| Article Number | 68001 | |
| Number of page(s) | 5 | |
| Section | Interdisciplinary Physics and Related Areas of Science and Technology | |
| DOI | https://doi.org/10.1209/0295-5075/96/68001 | |
| Published online | 15 November 2011 | |
Finite-enthalpy model parameters from DNA melting temperatures
Department of Physics, Federal University of Minas Gerais - 31270-901 Belo Horizonte-MG, Brazil
Received:
3
October
2011
Accepted:
31
October
2011
Peyrard-Bishop (PB) models are used for the study of denaturation in DNA. Unfortunately, there is little connection of these models to linear nearest-neighbour models which are extensively used for the calculation of melting temperatures in biochemistry. Here we use the Joyeux-Buyukdagli (JB) model, a variant of the PB model which incorporates stacking enthalpies, and carry out a fitting procedure to experimental melting temperatures where we let the enthalpies vary freely. We start out with a single value for the enthalpy for all combinations of base pairs and after the fitting we obtain a new set of enthalpies which correlate very strongly with the measured enthalpies. This result provides the needed support for the use of experimental enthalpies in the JB/PB model.
PACS: 87.14.gk – DNA / 87.15.Zg – Phase transitions / 87.15.A- – Theory, modeling, and computer simulation
© EPLA, 2011
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