Volume 100, Number 6, December 2012
|Number of page(s)||5|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||08 January 2013|
The three different phases in the dynamics of chemical reaction networks and their relationship to cancer
1 A.I. Alikhanyan National Science Laboratory (Yerevan Physics Institute) Foundation Alikhanian Brothers St. 2, Yerevan 375036, Armenia
2 Institute of Physics, Academia Sinica - Nankang, Taipei 11529, Taiwan
3 EcolePolytechnique, Laboratoire d' Informatique - 91128 Palaiseau France, EU
4 Service d'oncologie, Hôpital Raymond Poincaré - Garches, France, EU
Received: 28 September 2012
Accepted: 27 November 2012
We investigate the catalytic reactions model used in cell modeling. The reaction kinetics is defined through the energies of different species of molecules following a random independent distribution. The related statistical physics model has three phases and these three phases emerge in the dynamics: fast dynamics phase, slow dynamic phase and ultra-slow dynamic phase. The phenomenon we found is rather general, and does not depend on the details of the model. We assume as a hypothesis that the transition among these phases (glassiness degrees) is related to cancer. The imbalance in the rate of processes between key aspects of the cell (gene regulation, protein-protein interaction, metabolical networks) creates a change in the fine tuning among these key aspects, affects the logics of the cell and initiates cancer. It is probable that cancer is a change of phase resulting from increased and deregulated metabolic reactions.
PACS: 87.18.-h – Biological complexity / 75.10.Nr – Spin-glass and other random models
© EPLA, 2012
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