Volume 107, Number 6, September 2014
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||24 September 2014|
Conductance of single microRNAs chains related to the autism spectrum disorder
1 Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte 59072-970, Natal- RN, Brazil
2 Departamento de Física, Instituto Federal de Educação, Ciência e Tecnologia do Maranhão 65030-005, São Luís-MA, Brazil
3 Departamento de Ciências Biológicas, Universidade Federal do Piauí - 64800-000, Floriano-PI, Brazil
4 Instituto Federal de Educação, Ciência e Tecnologia do Piauí - 64000-040, Teresina-PI, Brazil
5 Instituto Federal de Educação, Ciência e Tecnologia do Ceará - 60040-531, Fortaleza-CE, Brazil
6 Departamento de Física, Universidade Federal do Ceará - 60455-760, Fortaleza-CE, Brazil
Received: 15 April 2014
Accepted: 2 September 2014
The charge transport properties of single-stranded microRNAs (miRNAs) chains associated to autism disorder were investigated. The computations were performed within a tight-binding model, together with a transfer matrix technique, with ionization energies and hopping parameters obtained by quantum chemistry method. Current-voltage curves of twelve miRNA chains related to the autism spectrum disorders were calculated and analysed. We have obtained both semiconductor and insulator behavior, and a relationship between the current intensity and the autism-related miRNA bases sequencies, suggesting that a kind of electronic biosensor can be developed to distinguish different profiles of autism disorders.
PACS: 82.39.Jn – Charge (electron, proton) transfer in biological systems / 73.40.Rw – Metal-insulator-metal structures / 87.14.gn – RNA
© EPLA, 2014
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