| Issue |
EPL
Volume 112, Number 5, December 2015
|
|
|---|---|---|
| Article Number | 58002 | |
| Number of page(s) | 6 | |
| Section | Interdisciplinary Physics and Related Areas of Science and Technology | |
| DOI | https://doi.org/10.1209/0295-5075/112/58002 | |
| Published online | 18 December 2015 | |
A mechanical model for guided motion of mammalian cells
Department of Physics, Philipps-Universität Marburg and LOEWE Center for Synthetic Microbiology Marburg, Germany
Received: 22 June 2015
Accepted: 30 November 2015
We introduce a generic, purely mechanical model for environment-sensitive motion of mammalian cells that is applicable to chemotaxis, haptotaxis, and durotaxis as modes of motility. It is able to theoretically explain all relevant experimental observations, in particular, the high efficiency of motion, the behavior on inhomogeneous substrates, and the fixation of the lagging pole during motion. Furthermore, our model predicts that efficiency of motion in following a gradient depends on cell geometry (with more elongated cells being more efficient).
PACS: 87.17.Jj – Cell locomotion, chemotaxis / 87.17.Aa – Modeling, computer simulation of cell processes
© EPLA, 2015
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.