Volume 115, Number 6, September 2016
|Number of page(s)||7|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||04 November 2016|
Stochastic single-molecule dynamics of synaptic membrane protein domains
Department of Physics & Astronomy and Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California - Los Angeles, CA 90089, USA
Received: 8 September 2016
Accepted: 17 October 2016
Motivated by single-molecule experiments on synaptic membrane protein domains, we use a stochastic lattice model to study protein reaction and diffusion processes in crowded membranes. We find that the stochastic reaction-diffusion dynamics of synaptic proteins provide a simple physical mechanism for collective fluctuations in synaptic domains, the molecular turnover observed at synaptic domains, key features of the single-molecule trajectories observed for synaptic proteins, and spatially inhomogeneous protein lifetimes at the cell membrane. Our results suggest that central aspects of the single-molecule and collective dynamics observed for membrane protein domains can be understood in terms of stochastic reaction-diffusion processes at the cell membrane.
PACS: 87.16.-b – Subcellular structure and processes / 87.19.lp – Pattern formation: activity and anatomic / 87.10.Mn – Stochastic modeling
© EPLA, 2016
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