Volume 116, Number 3, November 2016
|Number of page(s)||6|
|Published online||22 December 2016|
Nonequilibrium dissipation in living oocytes
1 Laboratoire Matière et Systèmes Complexes, UMR 7057 CNRS/P7, Université Paris Diderot 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France
2 Laboratoire Physico-Chimie Curie, Institut Curie, PSL Research University, CNRS UMR168 75005, Paris, France
3 Sorbonne Universités, UPMC Univ Paris 06 - 75005, Paris, France
4 Department of Physics, California State University - Fullerton, CA 92831, USA
5 CIRB, Collège de France, CNRS-UMR7241, INSERM-U1050 - 75231 Paris, Cedex 05, France
6 Department of Chemical Physics, Weizmann Institute of Science - 76100 Rehovot, Israel
7 Department of Chemistry, University of California - Berkeley, CA, 94720, USA
Received: 20 September 2016
Accepted: 1 December 2016
Living organisms are inherently out-of-equilibrium systems. We employ recent developments in stochastic energetics and rely on a minimal microscopic model to predict the amount of mechanical energy dissipated by such dynamics. Our model includes complex rheological effects and nonequilibrium stochastic forces. By performing active microrheology and tracking micron-sized vesicles in the cytoplasm of living oocytes, we provide unprecedented measurements of the spectrum of dissipated energy. We show that our model is fully consistent with the experimental data, and we use it to offer predictions for the injection and dissipation energy scales involved in active fluctuations.
PACS: 05.40.-a – Fluctuation phenomena, random processes, noise, and Brownian motion / 05.10.Gg – Stochastic analysis methods (Fokker-Planck, Langevin, etc.) / 87.10.Mn – Stochastic modeling
© EPLA, 2016
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