Volume 127, Number 2, July 2019
|Number of page(s)||7|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||02 September 2019|
Stability of DNA passing through different geometrical pores
1 Department of Physics, BITS Pilani - Pilani campus, India-333031
2 Center for Computational Biology, The University of Kansas - Lawrence, KS 66047, USA
Received: 21 January 2019
Accepted: 10 July 2019
The recent years witnessed significant advances in nanopore technology and the DNA sequencing. One of the efficient methods for DNA sequencing is denaturation mapping of the DNA molecule that is trapped inside a cylindrical geometry. In this paper, we investigate the denaturation of homogeneous as well as heterogeneous DNA molecules which are confined in a conical as well as cylindrical geometric space. For the conically shaped confinement, we study the effect of the cone angle and the pore width on the melting profile of homogeneous DNA molecules. Similarly, for the cylindrically shaped confinement, we investigate the effect of the cylinder diameter on the melting profile of homogeneous and heterogeneous DNA molecules. We consider the conditions when DNA is partially inside the confined space and partially outside the confined space. For the investigation, we vary the fraction of base pairs that remains inside the space and calculate the denaturation profile of DNA molecules in each condition.
PACS: 87.14.gk – DNA / 87.15.Zg – Phase transitions / 87.15.A- – Theory, modeling, and computer simulation
© EPLA, 2019
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