Volume 135, Number 2, July 2021
|Number of page(s)||7|
|Section||Electromagnetism, Optics, Acoustics, Heat Transfer, Classical Mechanics, and Fluid Dynamics|
|Published online||21 September 2021|
Cytoplasmic streaming in C. elegans: Forces that drive oogenesis
1 Center for Research in Nanotechnology and Science, Indian Institute of Technology - Mumbai-400076, India
2 Department of Civil Engineering, Indian Institute of Technology - Mumbai-400076, India
3 Department of Physics, Indian Institute of Technology - Mumbai-400076, India
Received: 3 November 2020
Accepted: 13 July 2021
In the gonad of C. elegans worms, germ cells form the outer lining of the central tube, the rachis, which carries a cytoplasmic flow. The porous interface between the germ cells and rachis allows a radial flow of cytoplasm across the interface. In the upstream, the flow at the interface is radially inwards boosting the main cytoplasmic flow in the rachis, while in the downstream the flow is radially outward feeding the germ cells to become oocytes. We analyze the cytoplasmic flow in the rachis as a flow in a porous tube of varying width, with spatially heterogeneous flow injection or leakage rates. Taking the geometry of the rachis into account, we predict properties of the rachis flow, such as pressure gradients and spatially heterogeneous flow speeds. Based on these, we speculate how directions of sub-flows between germ cells and rachis could be regulated for the development of healthy oocytes. Knowledge of this connection between micro-scale flow mechanics and physiological parameters may then also help us understand the abnormalities of reproduction in C. elegans worms with mutations or pathologies.
© 2021 EPLA
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.