Issue |
EPL
Volume 146, Number 5, June 2024
|
|
---|---|---|
Article Number | 57001 | |
Number of page(s) | 5 | |
Section | Biological and soft matter physics | |
DOI | https://doi.org/10.1209/0295-5075/ad4ac2 | |
Published online | 21 June 2024 |
Membrane protein clustering from tension and multibody interactions
Université Paris Cité, CNRS, Laboratoire Matière et Systèmes Complexes (MSC) - F-75013 Paris, France
Received: 21 February 2024
Accepted: 13 May 2024
The point-curvature model for membrane protein inclusions is shown to capture multibody interactions very well. Using this model, we find that the interplay between membrane tension and multibody interactions results in a collective attraction of oppositely curved inclusions tending to form antiferromagnetic structures with a square lattice. This attraction can produce a phase separation between curved and non-curved proteins, resulting in the clustering of curved proteins. We also show that the many-body repulsion between identical curved proteins is enhanced by membrane tension. This can lead to the dissolution of clusters stabilized by short-range forces when the tension is increased. These new phenomena are biologically relevant and could be investigated experimentally.
© 2024 EPLA
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.