| Issue |
Europhys. Lett.
Volume 60, Number 6, December 2002
|
|
|---|---|---|
| Page(s) | 875 - 881 | |
| Section | Condensed matter: structure, mechanical and thermal properties | |
| DOI | https://doi.org/10.1209/epl/i2002-00299-3 | |
| Published online | 01 December 2002 | |
Extravasation of adhering vesicles
Laboratoire de Physico-Chimie Théorique and FR CNRS 2438
“Matière et Systèmes Complexes”-ESPCI 10 rue Vauquelin,
F-75231 Paris cedex 05, France
Received:
22
July
2002
Accepted:
4
October
2002
We study how the passage of lipid vesicles through a small pore
can be induced by the difference in non-specific adhesion energy
between the two sides of the substrate bearing the pore. This
process is inspired from the extravasation of cells or liposomes
from blood vessels, which involves adhesion binders. We study
the adhesion-dominated regime and we show that the passage of a
vesicle of volume V and area A is selective in terms of the
reduced volume 
. Extravasation occurs for
adhesion ratios of order unity. We also consider the possibility
of pressure-induced extravasation in the presence of adhesion.
Finally, we propose a micro-device based on adhesion-induced
extravasation, which is designed to sort vesicles according to
their deflatedness.
PACS: 68.08.Bc – Wetting / 87.16.Dg – Membranes, bilayers, and vesicles / 87.17.Jj – Cell locomotion; chemotaxis and related directed motion
© EDP Sciences, 2002
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