Issue |
Europhys. Lett.
Volume 67, Number 4, August 2004
|
|
---|---|---|
Page(s) | 669 - 675 | |
Section | Interdisciplinary physics and related areas of science and technology | |
DOI | https://doi.org/10.1209/epl/i2004-10091-y | |
Published online | 01 August 2004 |
Evidence of an inverted hexagonal phase
in self-assembled phospholipid-
-metal complexes
1
Dipartimento di Fisica e Ingegneria dei Materiali e del Territorio and INFM Università Politecnica delle Marche - Via Brecce Bianche, 60131 Ancona, Italy
2
Dipartimento di Scienze dei Materiali e della Terra, Università Politecnica delle Marche - Via Brecce Bianche, 60131 Ancona, Italy
3
European Synchrotron Radiation Facility - BP 220, F-38043 Grenoble Cedex, France
Received:
27
April
2004
Accepted:
7
June
2004
We report the first observation of an inverted hexagonal phase of
phospholipid-DNA-metal complexes. These ternary complexes are
formed in a self-assembled manner when water solutions of
neutral lipid dioleoylphosphatidylethanolamine (DOPE), DNA and
divalent metal cations (;
,
,
,
) are mixed, which represents a striking
example of supramolecular chemistry. The structure, derived from
synchrotron X-ray diffraction, consists of cylindrical DNA
strands coated by neutral lipid monolayers and arranged on a
two-dimensional hexagonal lattice (
). Besides the
fundamental aspects, DOPE-DNA-
complexes may be of
great interest as efficient nonviral delivery systems in gene
therapy applications because of the low inherent cytotoxicity and
the potential high transfection efficiency.
PACS: 87.14.Cc – Lipids / 87.14.Gg – DNA, RNA / 61.10.-i – X-ray diffraction and scattering
© EDP Sciences, 2004
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.