Volume 70, Number 4, May 2005
|Page(s)||541 - 547|
|Section||Interdisciplinary physics and related areas of science and technology|
|Published online||22 April 2005|
Salt-induced condensation in actin-DNA mixtures
Department of Materials Science & Engineering, Department of Physics Department of Bioengineering, University of Illinois at Urbana-Champaign Urbana, IL 61801, USA
2 Isaac Newton Institute for Mathematical Sciences - Cambridge, CB3 0EH, UK
3 Institute for Advanced Studies in Basic Sciences - Zanjan 45195-159, Iran
4 Department of Applied Mathematics, University of Leeds - Leeds LS2 9JT, UK
Corresponding author: email@example.com
Accepted: 24 March 2005
Multivalent ions can induce condensation of like-charged polyelectrolytes into compact states, a process that requires different ion valence for different polyelectrolyte species. We have examined the trivalent ion-induced condensation behavior in binary anionic polyelectrolyte mixtures consisting of DNA coils and F-actin rods, and observe a micro-phase separation between the two polyelectrolytes into coexisting finite-sized F-actin bundles and DNA toroids. Further, by increasing the DNA volume fraction in the mixture, condensed F-actin bundles can be completely destabilized, leading to only DNA condensation within the mixture. We examine a number of possible causes and propose a model based on polyelectrolyte competition for ions.
PACS: 82.35.Rs – Polyelectrolytes / 82.35.Pq – Biopolymers, biopolymerization / 87.15.Aa – Theory and modeling; computer simulation
© EDP Sciences, 2005
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