Volume 77, Number 4, February 2007
|Number of page(s)||5|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||05 February 2007|
Close contact fluctuations: The seeding of signalling domains in the immunological synapse
Mathematics Institute, University of Warwick - Coventry CV4 7AL, UK
Accepted: 12 December 2006
We analyse the size and density of thermally induced regions of close contact in cell : cell contact interfaces within a harmonic potential approximation, estimating these regions to be below one-tenth of a micron across. Our calculations indicate that as the distance between the close contact threshold depth and the mean membrane-membrane separation increases, the density of close contact patches decreases exponentially while there is only a minimal variation in their mean size. The technique developed can be used to calculate the probability of first crossing in reflection symmetry violating systems.
PACS: 87.16.Dg – Membranes, bilayers, and vesicles / 05.40.-a – Fluctuation phenomena, random processes, noise, and Brownian motion / 87.10.+e – General theory and mathematical aspects
© Europhysics Letters Association, 2007
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