| Issue |
EPL
Volume 81, Number 5, March 2008
|
|
|---|---|---|
| Article Number | 56003 | |
| Number of page(s) | 6 | |
| Section | Condensed Matter: Structural, Mechanical and Thermal Properties | |
| DOI | https://doi.org/10.1209/0295-5075/81/56003 | |
| Published online | 18 February 2008 | |
Protein adsorption kinetics in different surface potentials
1
Department of Experimental Physics, Saarland University - 66041 Saarbrücken, Germany
2
Department of Theoretical Physics, Saarland University - 66041 Saarbrücken, Germany
Received:
15
May
2007
Accepted:
11
January
2008
We have studied the adsorption kinetics of the protein amylase at solid/liquid interfaces. Offering substrates with tailored properties, we are able to separate the impact of short- and long-range interactions. By means of a colloidal Monte Carlo approach including conformational changes of the adsorbed proteins induced by density fluctuations, we develop a scenario that is consistent with the experimentally observed three-step kinetics on specific substrates. Our observations show that not only the surface chemistry determines the properties of an adsorbed protein layer but also the van der Waals contributions of a composite substrate may lead to non-negligible effects.
PACS: 68.47.Pe – Langmuir-Blodgett films on solids; polymers on surfaces; biological molecules on surfaces / 68.43.-h – Chemisorption/physisorption: adsorbates on surfaces / 87.14.E- – Proteins
© EPLA, 2008
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.