Anomalous reaction kinetics and domain formation on crowded membranes
Cellular Biophysics Group, German Cancer Research Center, Im Neuenheimer Feld 280 - D-69120 Heidelberg, Germany, EU
2 Institut für Theoretische Physik - Philosophenweg 19, Universität Heidelberg, D-69120 Heidelberg, Germany, EU
3 Experimental Physics I, University of Bayreuth - Universitätsstr. 30, D-95440 Bayreuth, Germany, EU
Accepted: 28 February 2011
Using particle-based simulations, we show that anomalous diffusion in two-dimensional (2D) environments induces a strongly fractal reaction kinetics, i.e. time-dependent rate coefficients. While non-classical kinetics is anticipated already for normal diffusion due to the compactness of Brownian motion in 2D, the effect is even more pronounced when particles move via subdiffusion. As a consequence, strong reactant segregation is observed. Based on these findings, we argue that the experimentally observed subdiffusion of proteins on biomembranes may serve as a means to foster biochemical reactions in well-defined “hot spots” without the need for diffusion barriers.
PACS: 82.39.-k – Chemical kinetics in biological systems / 82.20.Wt – Computational modeling; simulation / 82.33.Ln – Reactions in sol gels, aerogels, porous media
© EPLA, 2011