Dipole angular entropy techniques for intron-exon segregation in DNA

Department of Electrical Engineering, IIT Delhi - Hauz Khas, New Delhi, India

^a eez107514@iitd.ac.in
^b rbose@ee.iitd.ac.in

Received: 16 October 2011
Accepted: 20 March 2012

Abstract

We propose techniques for computing the angular entropies of DNA sequences, based on the orientations of the dipole moments of the nucleotide bases. The angles of the dipole moment vectors of the bases are used to compute the dipole angular entropy and the Fourier harmonics of the angles are used to compute the dipole angular spectral entropy for a given sequence. We also show that the coding (exons) and noncoding (introns) regions of the DNA can be segregated based on their dipole angular entropies and dipole angular spectral entropies. Segregation using these techniques is found to be computationally faster and more accurate than the previously reported methods. The proposed techniques can also be improvised to use the magnitude of the dipole moments of the bases in addition to the angles.