Volume 104, Number 1, October 2013
|Number of page(s)||5|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||24 October 2013|
How charge fluctuations modulate complexation of DNA around a histone cylinder
Department of Physics and PCTP, Pohang University of Science and Technology - Pohang, 790-784, South Korea
Received: 22 July 2013
Accepted: 30 September 2013
It is an enigma that in a nucleosome complex, a single DNA winds around a histone protein core about 1.6–1.8 times. We find that the optimal winding can be given by the charge density fluctuations on the DNA contour due to multivalent counterions binding and unbinding in a physiological ionic background. From a model free energy of the DNA wound on the histone cylinder, where the charge fluctuations induce the intra-DNA attraction, we establish the conditions and a phase diagram for stability of the complex as a function of the salt and divalent cations concentrations.
PACS: 82.35.Rs – Polyelectrolytes / 87.15.A- – Theory, modeling, and computer simulation
© EPLA, 2013
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.