Volume 105, Number 1, January 2014
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||03 February 2014|
Exploring cores and skeletons in oscillatory gene regulatory networks by a functional weight approach
1 Department of Physics, Beijing Normal University - Beijing 100875, China
2 Department of Bioengineering and Therapeutic Sciences, University of California - San Francisco, CA 94158, USA
Received: 23 October 2013
Accepted: 2 January 2014
The topological structures of complex networks are often very complicated and there are huge amount of data in their dynamics. It is important to extract useful information from the available data and to explore some simple reduced structures (if they exist) which play key roles determining different functions of the networks. In this paper, models of gene regulatory networks (GRNs) are studied and a method of functional weight analysis is proposed to quantitatively measure the importance of all topological interactions from the data of oscillation. This method allows us to obtain some simple skeleton interactions and core structures. The latter play the role of oscillation sources while the former reveal the main signal propagation paths from the sources throughout the networks. Different control strategies and detailed statistical results demonstrate the validity, significance and efficiency of the analysis.
PACS: 89.75.Fb – Structures and organization in complex systems / 05.10.-a – Computational methods in statistical physics and nonlinear dynamics / 05.65.+b – Self-organized systems
© EPLA, 2014
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.