Volume 71, Number 5, September 2005
|Page(s)||852 - 858|
|Section||Interdisciplinary physics and related areas of science and technology|
|Published online||29 July 2005|
Stochastic approach to DNA breathing dynamics
NORDITA, Nordic Institute for Theoretical Physics Blegdamsvej 17, DK-2100 Copenhagen Ø, Denmark
Corresponding author: email@example.com
Accepted: 28 June 2005
We propose a stochastic Gillespie scheme to describe the temporal fluctuations of local denaturation zones in double-stranded DNA as a single-molecule time series. It is demonstrated that the model recovers the equilibrium properties. We also study measurable dynamical quantities such as the bubble size autocorrelation function. This efficient computational approach will be useful to analyse in detail recent single-molecule experiments on clamped homopolymer breathing domains, to probe the parameter values of the underlying Poland-Scheraga model, as well as to design experimental conditions for similar setups.
PACS: 87.15.Aa – Theory and modeling; computer simulation / 82.37.-j – Single molecule kinetics / 87.14.Gg – DNA, RNA
© EDP Sciences, 2005
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