Volume 85, Number 1, January 2009
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||16 December 2008|
Stochastic extinction of viral infectivity through the action of defectors
Centro de Astrobiología, CSIC-INTA - Ctra. de Ajalvir km. 4, 28850 Torrejón de Ardoz, Madrid, Spain, EU
Corresponding author: firstname.lastname@example.org
Accepted: 24 November 2008
The high error rates of RNA viruses at replication suggest they might be close to the extinction threshold predicted by quasispecies theory. Hence, moderate increases in the mutation rate could drive them to extinction. In persistent infections of an RNA virus treated with a mutagen, it has been observed that infectivity eventually disappears, although the replicative ability of the virus is not affected. By means of a simple model that takes into account two phenotypic traits, we demonstrate that extinction is a purely stochastic phenomenon caused by the intermittent outbreaks of a defective, non-infective subpopulation. The transition between dynamics dominated by population fluctuations (finite system size N) and the mean-field behavior (N ) is characterized. We discuss the implications of this alternative pathway to viral extinction.
PACS: 87.19.xd – Viral diseases / 87.10.-e – General theory and mathematical aspects / 87.23.-n – Ecology and evolution
© EPLA, 2008
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.