Volume 100, Number 4, November 2012
|Number of page(s)||6|
|Section||Interdisciplinary Physics and Related Areas of Science and Technology|
|Published online||27 November 2012|
Synchronization with mismatched synaptic delays: A unique role of elastic neuronal latency
1 Gonda Interdisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University Ramat-Gan 52900, Israel
2 Department of Physics, Bar-Ilan University - Ramat-Gan 52900, Israel
3 Network Biology Research Laboratories, Technion - Israel Institute of Technology - Haifa 32000, Israel
Received: 18 October 2012
Accepted: 14 November 2012
We show that the unavoidable increase in neuronal response latency to ongoing stimulation serves as a nonuniform gradual stretching of neuronal circuit delay loops and emerges as an essential mechanism in the formation of various types of neuronal timers. Synchronization emerges as a transient phenomenon without predefined precise matched synaptic delays. These findings are described in an experimental procedure where conditioned stimulations were enforced on a circuit of neurons embedded within a large-scale network of cortical cells in vitro, and are corroborated by neuronal simulations. They evidence a new cortical time scale based on tens of μs stretching of neuronal circuit delay loops per spike, and with realistic delays of a few milliseconds, synchronization emerges for a finite fraction of neuronal circuit delays.
PACS: 84.35.+i – Neural networks / 87.19.lm – Synchronization in the nervous system / 87.19.ll – Models of single neurons and networks
© EPLA, 2012
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