Volume 116, Number 4, November 2016
|Number of page(s)||7|
|Section||Condensed Matter: Structural, Mechanical and Thermal Properties|
|Published online||28 December 2016|
Hours of high-frequency stimulations reveal intracellular neuronal trends in vivo
1 Gonda Multidisciplinary Brain Research Center, and the Goodman Faculty of Life Sciences, Bar-Ilan University 52900 Ramat Gan, Israel
2 Department of Physics, Bar-Ilan University - 52900 Ramat Gan, Israel
3 MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital Charlestown, MA 02119, USA
Received: 20 September 2016
Accepted: 7 December 2016
The neuronal response to controlled stimulations in vivo has been classically estimated using a limited number of events. Here we show that hours of high-frequency stimulations and recordings of neurons in vivo reveal previously unknown response phases of neurons in the intact brain. Results indicate that for stimulation frequencies below a critical neuronal characteristic frequency, fc, response timings are stabilized to tens-of-microseconds accuracy. For stimulation frequencies exceeding fc the firing frequency is saturated and independent of the stimulation frequency, as a result of random neuronal response failures. This neuronal plasticity, previously shown in vitro, supports a robust mechanism for low firing rates on a network level.
PACS: 64.60.aq – Networks / 87.18.Sn – Neural networks and synaptic communication / 05.45.Tp – Time series analysis
© EPLA, 2016
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