Volume 134, Number 6, June 2021
|Number of page(s)||5|
|Published online||03 September 2021|
Significant anisotropic neuronal refractory period plasticity
1 Department of Physics, Bar- Ilan University - Ramat-Gan, 52900, Israel
2 Gonda Interdisciplinary Brain Research Center and the Goodman Faculty of Life Sciences, Bar- Ilan University Ramat-Gan, 52900, Israel
Received: 19 May 2021
Accepted: 23 July 2021
Refractory periods are an unavoidable feature of excitable elements, resulting in necessary time-lags for re-excitation. Herein, we measure neuronal absolute refractory periods (ARPs) in synaptic blocked neuronal cultures. In so doing, we show that their duration can be significantly extended by dozens of milliseconds using preceding evoked spikes generated by extracellular stimulations. The ARP increases with the frequency of preceding stimulations, and saturates at the intermittent phase of the neuronal response latency, where a short relative refractory period might appear. Nevertheless, preceding stimulations via a different extracellular route does not affect the ARP. It is also found to be independent of preceding intracellular stimulations. All these features strongly suggest that the anisotropic ARPs originate in neuronal dendrites. The results demonstrate the fast and significant plasticity of the neuronal ARP, depending on the firing activity of its connecting neurons, which is expected to affect network dynamics.
© 2021 EPLA
Current usage metrics show cumulative count of Article Views (full-text article views including HTML views, PDF and ePub downloads, according to the available data) and Abstracts Views on Vision4Press platform.
Data correspond to usage on the plateform after 2015. The current usage metrics is available 48-96 hours after online publication and is updated daily on week days.
Initial download of the metrics may take a while.